In a human female, the fertility period extends from the age of puberty, i.e. about 12-13 years up to menopause, i.e. 45-50 years. The stage of puberty is marked by the appearance of secondary sexual characteristics.

The onset of menstruation in a female is called menarche. It starts at an age of about 11-13 years. The permanent stoppage of menstruation in a female is called menopause. It occurs at an age of about 45-50 years. At the time of menopause, ovulation and menstruation stop and the reproductive organs decrease in size. Between puberty and menopause, the female reproductive system passes through a regular monthly sequence of events called the menstrual cycle.

During menstrual cycle, an ovum is matured and released once every 28 days. However, many a times, due to some reasons this period may increase or decrease. The menstrual cycle starts with the menstrual flow, during which the cellular lining of the uterus, with blood flow, is shed off. This process continues for 3-4 days.

From the 5th upto the 13th day of the onset of menstrual cycle, growth and maturation of the Graafian follicle takes place. Graafian follicle is the final stage in the maturation of an ovum inside the ovary. It consists of an ovum and a mass of cells surrounding it. The Graafian follicle also produces a hormone, oestrogen, which stimulates the uterus to prepare itself to receive the ovum. The cells lining the uterus grow rapidly and develop a dense network of blood vessels.

Ovulation takes place 13-14 days after the onset of menstruation. The Graafian follicle ruptures to release the ovum. The cells of the ruptured follicle form the corpus luteum which secretes the hormone, progesterone. The ovum reaches the uterus via the fallopian tube on the 13th or 14th day and remains there up to the 16th day (for 48-72 hours). If the ovum does not receive any sperm during this period it starts degenerating.

At the end of the 28th day this ovum is rejected along with the uterine lining. This marks the start of a slow disintegration of the thickened lining of the uterus and the next menstrual cycle.

What happens to the menstrual cycle if the ovum receives sperm and fertilization occurs?

If the ovum receives sperm and gets fertilized, menstruation (and ovulation) cease for as long as the woman is pregnant. This is because progesterone is produced continuously first by the corpus luteum (which persists in the ovary) and later by the placenta.